Researchers have uncovered a surprising new role for the HSL protein: beyond breaking down fat, it also works inside the nucleus of fat cells to keep them functioning properly. When HSL is missing, fat tissue doesn’t expand as expected— instead, it shrinks, leading to lipodystrophy. This unexpected discovery helps explain why both obesity and fat-loss disorders share similar health risks, and it opens up fresh paths for understanding metabolic diseases at a time when obesity affects billions worldwide.
Regulatory systems have limits. Some people will have ‘abnormal’ HSL regulation (now needs considering). For most people, how we live, move and eat can significantly outweight the built in regulatory systems, however well balanced they are.